Clinical Xenotransplantation Updates

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Monday, June 6, 2022

11:15 AM - 12:30 PM

Attendee Type Access: In-person & Virtual Only

Presentations with Panel Discussion / Question and Answer at the end of the session.

The shortage of available donor organs remains the most pressing issue for the field of transplantation.  Although xenotransplantation, the use of a non-human species as an unlimited source of transplantable organs, has been proposed as a solution since the infancy of clinical transplantation it has failed to become a reality and is often considered an unobtainable goal.  More recently with the development of cutting-edge gene editing technology coupled with advances in novel immunosuppression, preclinical models of xenotransplantation in heart, kidney and islet have achieved significant advances that the discussion surrounding clinical xenotransplantation has been rekindled.  Major advances in those efforts were recently reported with the use of genetically modified pig kidneys transplanted into two brain dead individuals along with the report of a genetically modified heart transplanted into a living human recipient under a compassionate use protocol.  These events may well mark the beginning of a new era in transplantation.  In this session members of the respective teams who performed these landmark procedures will briefly discuss their findings followed by a discussion with experts in the field regarding the ethics and practical considerations that will be required as we consider clinical trials in xenotransplantation.

11:15 AM – 12:30 PM
Moderators:
Andrew Adams, MD, PhD, University of Minnesota, Minneapolis, MN, USA
Matthew Levine, MD, PhD, University of Pennsylvania, Philadelphia, PA, USA

11:15 AM - 11:25 AM
Overview & Progress of Xenotransplant
A. Joseph Tector, MD, PhD, Miami Transplant Institute, Miami, FL, USA

11:25 AM - 11:35 AM
The NYU Experience
Robert Montgomery, MD, D.Phil, FACS, NYU Langone Health, New York, NY, USA

11:35 AM - 11:45 AM
The Maryland Experience
Muhammad Mohiuddin, MD, University of Maryland, Baltimore, MD, USA

11:45 AM - 11:55 AM
The UAB Experience
Jayme Locke, MD, MPH, FACS, FAST, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA

11:55 AM - 12:05 PM
Ethics
Brendan Parent, JD, New York University Grossman School of Medicine, New York, NY, USA

12:05 PM – 12:30 PM
Panelists:
Jay Fishman, MD, Massachusetts General Hospital - Harvard Medical School, Boston, MA, USA
A. Joseph Tector, MD, PhD, Miami Transplant Institute, Miami, FL, USA
Megan Sykes, MD, Columbia Center for Translational Immunology, Columbia University, New York, NY, USA